Combination therapy based on nano codelivery for overcoming cancer drug resistance
Hairui Wang, Yongzhuo Huang
Abstract
Multidrug resistance (MDR) has long been a major obstacle in the treatment of malignant tumors. Combination therapy provides a viable and promising strategy to overcome MDR. This article discusses the advantages of nano-based combination therapy and proposes a 3R delivery principle (right place, right time, and right dose) as a reference for development of cancer nanomedicine containing drug combinations. The article also reviews the strategies of nano-based codelivery, with emphasis on the techniques designed to overcome chemoresistance, enhance drug targeting delivery, and reduce immunosuppression.
Topics & Concepts
NanomedicineMultiple drug resistanceMedicineCombination therapyDrug resistanceCancer therapyDrug deliveryDrugImmunosuppressionCancerPharmacologyNanotechnologyImmunologyInternal medicineBiologyNanoparticleMaterials scienceMicrobiologyNanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques