Population Pharmacokinetic Analysis of Isoniazid among Pulmonary Tuberculosis Patients from China
Wei Jing, Zhaojing Zong, Bo‐Hao Tang, Jing Wang, Tingting Zhang, Shu’an Wen, Yi Xue, Naihui Chu, Wei Zhao, Hairong Huang
Abstract
; ≥10.52 μg·h/ml), and the 2-h INH serum concentrations (≥2.19 μg/ml), was associated with the strongest early bactericidal activity. The optimal dosages targeting the different indicators varied from 700 to 900 mg/day, 500 to 600 mg/day, and 300 mg/day for the rapid, intermediate, and slow acetylators, respectively. Furthermore, a PPK model for isoniazid among Chinese tuberculosis patients was established for the first time and suggested doses of approximately 800 mg/day, 500 mg/day, and 300 mg/day for fast, intermediate, and slow acetylators, respectively, after a trade-off between efficacy and the occurrence of side effects.