Modern metal-catalyzed and organocatalytic methods for synthesis of coumarin derivatives: a review
Sara Moghadam Farid, Behnoush Seifinoferest, Maral Gholamhosseyni, Bagher Larijani, Mohammad Mahdavi
Abstract
Coumarin is an important pharmaceutical structural motif, abundantly found in numerous commonly used drugs. Compounds containing this core show a broad spectrum of medicinal properties and biological activities. The increasing importance and wide usages of coumarin derivatives have drawn attention to its synthetic methods, among which metal-catalyzed and organocatalytic methods have proved the most effective. Several metal-catalyzed and/or organocatalytic synthetic strategies for coumarin have been investigated and reported in recent decades. This review focuses on more recent reports on catalysis methods for synthesizing coumarin and coumarin-like structures (including light-mediated methods and nano-catalysts), exploring the mechanistic aspects, simplicity, efficiency, repeatability, and other advantages and disadvantages of these methods.