Re-analysis of single-cell transcriptomics reveals a critical role of macrophage-like smooth muscle cells in advanced atherosclerotic plaque
Xue Gong, Yunchang Liu, Huiying Liu, Nian Cao, Liping Zeng, Miao Tian, Chunyu Zeng, Yijie Hu, Runjun Zhang, Yundai Chen, Gengze Wu
Abstract
Our study illustrates a comprehensive cell atlas and molecular landscape of advanced atherosclerotic lesion, which might renovate current understanding of SMC biology in atherosclerosis.
Topics & Concepts
TransdifferentiationBiologyTranscriptomeCell biologyProinflammatory cytokineMacrophagePhenotypeCellFoam cellCell typeInflammationImmunologyGene expressionIn vitroGeneticsGeneStem cellAtherosclerosis and Cardiovascular DiseasesSingle-cell and spatial transcriptomicsImmune cells in cancer