IGF-1 promotes multiple myeloma progression through PI3K/Akt-mediated epithelial-mesenchymal transition
Yue Peng, Fangmei Li, Peihua Zhang, Xiaman Wang, Ying Shen, Yuandong Feng, Yachun Jia, Ru Zhang, Jinsong Hu, Aili He
Topics & Concepts
VimentinEpithelial–mesenchymal transitionPI3K/AKT/mTOR pathwayMesenchymal stem cellProtein kinase BCancer researchCell migrationSmall interfering RNABiologyMetastasisCell growthFlow cytometryTransfectionCellCell biologyChemistrySignal transductionMolecular biologyCell cultureImmunologyCancerGeneticsImmunohistochemistryCancer Cells and MetastasisMultiple Myeloma Research and TreatmentsPI3K/AKT/mTOR signaling in cancer