Highly Stereoselective Ugi/Pictet–Spengler Sequence
Bidong Zhang, Katarzyna Kurpiewska, Alexander Dömlingꝉ
Abstract
]pyrazine-dione from readily accessible starting materials. The alkaloid-type polycyclic scaffold with potential bioactivity was achieved by a multicomponent reaction (MCR)-based protocol via a Ugi four-component reaction and Pictet-Spengler sequence under different conditions, yielding a diverse library of products.
Topics & Concepts
Pictet–Spengler reactionUgi reactionScaffoldChemistrySequence (biology)Nitrogen atomStereoselectivityCombinatorial chemistryPyrazineBiochemical engineeringComputational biologyStereochemistryComputer scienceOrganic chemistryBiologyBiochemistryEngineeringIsocyanideDatabaseGroup (periodic table)CatalysisMulticomponent Synthesis of HeterocyclesChemical Synthesis and AnalysisSynthesis and biological activity