Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
Guijun Shang, Conggang Zhang, Zhijian J. Chen, Xiao‐chen Bai, Xuewu Zhang
Topics & Concepts
Conformational changeLigand (biochemistry)StingDimerTransmembrane domainChemistryTetramerTransmembrane proteinBiophysicsStimulator of interferon genesBinding domainProtein structureCytoplasmStereochemistryBinding siteBiochemistryMembraneBiologyReceptorInnate immune systemEngineeringOrganic chemistryAerospace engineeringEnzymeinterferon and immune responsesViral Infections and VectorsInflammasome and immune disorders