A practical synthesis of 1,3-disubstituted cubane derivatives
Nahin Kazi, Marine C. Aublette, Sarah L. Allinson, S. C. Coote
Abstract
A robust multigram-scale synthesis of 1,3-disubstituted cubanes (previously only available on milligram-scale) is reported. The approach exploits a readily available enone intermediate previously used for the synthesis of 1,4-disubstituted cubanes, by introducing a novel Wharton transposition to access useful quantities of 1,3-disubstituted cubanes for diverse applications.
Topics & Concepts
CubaneChemistryCombinatorial chemistryStereochemistryOrganic chemistryMoleculeCoordination Chemistry and OrganometallicsAsymmetric Synthesis and CatalysisAxial and Atropisomeric Chirality Synthesis