Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity
Haytham O. Tawfik, Moataz A. Shaldam, Alessio Nocentini, Rofaida Salem, Hadia Almahli, Sara T. Al‐Rashood, Claudiu T. Supuran, Wagdy M. Eldehna
Abstract
CA I and II isoforms haven't been inhibited up to 100 µM. Furthermore, the target coumarins were assessed for their antitumor activity on NCI-59 human cancer types.
Topics & Concepts
CoumarinGene isoformIsozymeChemistryCarbonic anhydraseCancerCytosolEnzymeBiochemistryCancer cellStereochemistryInternal medicineGeneMedicineOrganic chemistryEnzyme function and inhibitionSynthesis and Catalytic ReactionsSynthesis and Biological Evaluation