Natural Selection On Synonymous Mutations in SARS-CoV-2 and the Impact On Estimating Divergence Time
Yuanyuan Yu, Yan Li, Yuran Dong, Xuekun Wang, Chunxiao Li, Wenqing Jiang
Abstract
To adapt to human host environment, synonymous mutations in SARS-CoV-2 are shaped by tRNA selection, energy cost and RNA structure.
Topics & Concepts
Selection (genetic algorithm)Natural selectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyCoronavirus disease 2019 (COVID-19)Silent mutationGeneticsDivergence (linguistics)2019-20 coronavirus outbreakTransfer RNAMutationHost (biology)VirologyEvolutionary biologyRNAComputational biologyGeneMedicineComputer scienceMissense mutationDiseaseOutbreakLinguisticsPhilosophyPathologyInfectious disease (medical specialty)Artificial intelligenceRNA and protein synthesis mechanismsCRISPR and Genetic EngineeringRNA modifications and cancer