Conditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells
Zachary J. Gerbec, Elaheh Hashemi, Arash Nanbakhsh, Sandra Holzhauer, Chao Yang, Ao Mei, Shirng‐Wern Tsaih, Angela Lemke, Michael J. Flister, Matthew J. Riese, Monica S. Thakar, Subramaniam Malarkannan
Abstract
, and subsequent gene expression analysis showed that PGC-1α mediates transcription required to maintain mitochondrial activity within the tumor microenvironment. Together, these data suggest that PGC-1α-dependent transcription of specific target genes is required for optimal NK cell function during the response to infection or tumor growth.
Topics & Concepts
BiologyEffectorCell biologyCytotoxic T cellConditional gene knockoutImmune systemTranscription (linguistics)Transcription factorCell growthMitochondrionGenePhenotypeIn vitroImmunologyGeneticsLinguisticsPhilosophyImmune Cell Function and InteractionCancer, Hypoxia, and MetabolismAdipose Tissue and Metabolism