Recent Advances of 1,3,5-Triazinanes in Aminomethylation and Cycloaddition Reactions
Jia‐Rong Chen, Dong Liang, Wen‐Jing Xiao
Abstract
1,3,5-Trisubstituted 1,3,5-triazinanes (hexahydro-1,3,5-triazines), as stable and readily available surrogates for formaldimines, have found extensive applications for the construction of various nitrogen-containing compounds. The formaldimines, formed in situ from this reagent class, can participate in various aminomethylation and cycloaddition reactions. This short review presents recent advances in this field with emphasis on the conceptual ideas behind the developed methodologies and the reaction mechanisms. 1 Introduction 2 Aminomethylations with 1,3,5-Triazinanes 3 Cycloadditions with 1,3,5-Triazinanes 3.1 Use of 1,3,5-Triazinanes as Two-Atom Synthons 3.2 Use of 1,3,5-Triazinanes as Three-Atom Synthons 3.3 Use of 1,3,5-Triazinanes as Four-Atom Synthons 3.4 Use of 1,3,5-Triazinanes as Six-Atom Synthons 4 Conclusions