Multiple Myeloma–Associated Ig Light Chain Crystalline Cast Nephropathy
Hirotoshi Matsumura, Yusuke Furukawa, Takashi Nakagaki, Chikako Furutani, Sayaka Osanai, Keiichi Noguchi, Masafumi Odaka, Masafumi Yohda, Hiroshi Ohtani, Yoshihiro Michishita, Yoshinari Kawabata, Atsushi Kitabayashi, Sho Ikeda, Mizuho Nara, Atsushi Komatsuda, Naoto Takahashi, Hideki Wakui
Abstract
Renal involvement is a common complication in multiple myeloma (MM), a malignant neoplasm arising from an abnormal proliferation of clonal plasma cells in the bone marrow.1 MM-associated renal disorders such as amyloidosis and cast nephropathy usually result from the extracellular deposition of monoclonal Ig free light chains (FLCs). Monoclonal Ig FLCs excreted in the urine are referred to as Bence–Jones proteins (BJPs).2
Topics & Concepts
MedicineImmunoglobulin light chainBence Jones proteinMultiple myelomaAmyloidosisMonoclonalBone marrowPlasma cellPathologyNephropathyAL amyloidosisMonoclonal antibodyComplicationUrineExtracellularAntibodyInternal medicineImmunologyEndocrinologyCell biologyBiologyDiabetes mellitusMultiple Myeloma Research and TreatmentsAmyloidosis: Diagnosis, Treatment, OutcomesDrug Transport and Resistance Mechanisms