Ex Vivo Lung Perfusion: Current Achievements and Future Directions
Nikhil K. Prasad, Chetan Pasrija, Tara Talaie, Alexander S. Krupnick, Yunge Zhao, Christine L. Lau
Abstract
There is a severe shortage in the availability of donor organs for lung transplantation. Novel strategies are needed to optimize usage of available organs to address the growing global needs. Ex vivo lung perfusion has emerged as a powerful tool for the assessment, rehabilitation, and optimization of donor lungs before transplantation. In this review, we discuss the history of ex vivo lung perfusion, current evidence on its use for standard and extended criteria donors, and consider the exciting future opportunities that this technology provides for lung transplantation.
Topics & Concepts
Economic shortageEx vivoLung transplantationLungMedicineTransplantationIntensive care medicinePerfusionIn vivoSurgeryRadiologyInternal medicineBiologyBiotechnologyPhilosophyGovernment (linguistics)LinguisticsTransplantation: Methods and OutcomesOrgan Transplantation Techniques and OutcomesMechanical Circulatory Support Devices