A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological Samples
Wei Guo, Shiqiang Yan, Chaoqiang Xiao, Dayong Shi, Qing Hua, Xiaowen Hao, Wenjuan Zhang, Xuming Zhuang
Abstract
Oseltamivir is a drug that has been widely used to prevent and treat influenza A and B. In this work, an ultrasensitive, simple, and novel electrochemiluminescence (ECL) sensor combined with molecularly imprinted polymers (MIP-ECL) based on a graphene-like two-dimensional material, Mxene quantum dots (MQDs) was constructed to selectively detect oseltamivir. A molecularly imprinted polymer membrane containing an oseltamivir template was constructed by electropolymerization and elution of modified MQDs on a glassy carbon electrode. Under optimized experimental conditions, the MIP-ECL sensor could detect oseltamivir in the range of 10−10 to 10−6 M (R2 = 0.9816), with a low limit of detection of 6.5 × 10−11 M (S/N = 3), and the recovery rates of oseltamivir in biological samples were 92.21–104.2%, with relative standard deviations of 3.70%~5.70%. The developed MIP-ECL sensor provides a new idea for detecting oseltamivir, which was successfully applied to the determination of oseltamivir in serum samples, indicating great potential for application in clinical diagnostics.