Coaxial bioprinting of a stentable and endothelialized human coronary artery-sized <i>in vitro</i> model
Ashfaq Ahmad, S. J. Kim, Yun‐Jin Jeong, Muhammad Soban Khan, Jinsoo Park, Dong‐Weon Lee, Changho Lee, Yeong‐Jin Choi, Hee-Gyeong Yi
Abstract
model compatible with cardiovascular stents. Using a coaxial nozzle, a tubular structure of human coronary artery (HCA) size is bioprinted with a collagen-based bioink, ensuring good biocompatibility and suitable rheological properties for printing. We precisely replicated the dimensions of the HCA, including its internal diameter and wall thickness, and simulated the vascular barrier functionality. To simplify post-processing, a pumpless perfusion bioreactor is fabricated to culture a HCA-sized model, eliminating the need for a peristaltic pump and enabling scalability for high-throughput production. This model is expected to accelerate stent development in the future.