Pillar[5]arene-derived covalent organic materials with pre-encoded molecular recognition for targeted and synergistic cancer photo- and chemotherapy
Yang Wang, Di Wang, Jian Wang, Jian Wang, Chenwei Wang, Jin Wang, Jin Wang, Yue Ding, Yong Yao
Abstract
By combining the precisely sized cavity of pillar[5]arene and photodynamic properties of porphyrin derivatives, novel COMs (P5COMs) as an efficient cancer therapy platform from aldehyde-modified pillar[5]arene (P5CHO) and tetra-(4-aminophenyl)porphyrin (TAPP) were fabricated successfully.
Topics & Concepts
PillarMolecular recognitionCovalent bondCancer chemotherapyChemistryNanotechnologyCancer researchCancerCombinatorial chemistryMaterials scienceMoleculeOrganic chemistryMedicineEngineeringInternal medicineStructural engineeringCovalent Organic Framework ApplicationsLuminescence and Fluorescent MaterialsMetal-Organic Frameworks: Synthesis and Applications