Chitosan-modified polymeric nanoparticles for the nose-to-brain drug delivery of paroxetine: an <i>in vitro</i> and <i>in vivo</i> evaluation
Surbhi Sharma, Pammi Gauba, Amit Tyagi, Shweta Dang
Abstract
Chitosan-modified PLGA nanoparticles can increase the therapeutic potential of the paroxetine drug by increasing the targeted delivery through a cellular uptake mechanism. The mucoadhesive polymers enhance drug delivery via the intranasal route.
Topics & Concepts
ChitosanNasal administrationDrug deliveryPLGAParoxetineIn vivoDrugPharmacologyNanotechnologyNanoparticleMaterials scienceChemistryBiomedical engineeringMedicineOrganic chemistryBiochemistrySerotoninReceptorBiotechnologyBiologyAdvanced Drug Delivery SystemsLipid Membrane Structure and BehaviorSupramolecular Self-Assembly in Materials