Diazaphospholene-Catalyzed Hydrodefluorination of Polyfluoroarenes with Phenylsilane via Concerted Nucleophilic Aromatic Substitution
Jingjing Zhang, Xiao Zhao, Jin‐Dong Yang, Jin‐Pei Cheng
Abstract
The metal-free catalytic C-F bond activation of polyfluoroarenes was achieved with diazaphospholene as the catalyst and phenylsilane as the terminal reductant. Density functional theory calculations suggested a concerted nucleophilic aromatic substitution mechanism.
Topics & Concepts
PhenylsilaneChemistryCatalysisRadical-nucleophilic aromatic substitutionNucleophilic substitutionNucleophilic aromatic substitutionNucleophilePhotochemistrySubstitution reactionMedicinal chemistryOrganic chemistryFluorine in Organic ChemistryCyclopropane Reaction MechanismsInorganic Fluorides and Related Compounds