Plasma Microbial Cell-Free DNA Sequencing from over 15,000 Patients Identified a Broad Spectrum of Pathogens
Sarah Y. Park, Eliza J Chang, Nathan A. Ledeboer, Kevin Messacar, Martin Lindner, Shivkumar Venkatasubrahmanyam, Judith C. Wilber, Marla Lay Vaughn, Sivan Bercovici, Bradley A. Perkins, Frederick S. Nolte
Abstract
spp., and 57 protozoan parasites) comprised 675 (3%) of all detections. This is the largest reported cohort of patients tested using plasma mcfDNA sequencing and represents the first report of a clinical grade metagenomic test performed at scale. Data reveal new insights into the breadth and complexity of potential pathogens identified.
Topics & Concepts
DNA sequencingPathogenCell-free fetal DNABiologyBroad spectrumInfectious disease (medical specialty)DNAComputational biologyMicrobiologyGeneticsDiseaseChemistryMedicinePathologyCombinatorial chemistryPrenatal diagnosisPregnancyFetusInfective Endocarditis Diagnosis and ManagementBacterial Identification and Susceptibility TestingAntibiotic Resistance in Bacteria