Palladium-Catalyzed Regioselective C3-Allylic Alkylation of 2-Aryl Imidazopyridines with MBH Carbonates
Tamilarasu Murugesan, Afna Elikkottil, Kaliyamoorthy Alagiri
Abstract
Imidazopyridine is an important framework that constitutes several pharmaceutical drugs and biologically active molecules. Herein, we present the palladium-catalyzed regioselective C3-allylic alkylation of 2-aryl imidazopyridines with MBH carbonates. This strategy furnishes a broad spectrum of C3-allylated imidazopyridines, and their structures have been unequivocally established using X-ray analysis. Besides, the reaction can be easily scaled up on a gram scale, and the ensuing product can be smoothly manipulated into synthetically useful entities.
Topics & Concepts
ChemistryRegioselectivityImidazopyridinePalladiumArylTsuji–Trost reactionCombinatorial chemistryCatalysisAlkylationAllylic rearrangementOrganic chemistryMoleculeAlkylCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCatalytic Cross-Coupling Reactions