Effects of the adiponectin mimetic compound ALY688 on glucose and fat metabolism in visceral and subcutaneous rat adipocytes
Daniel Da Eira, Shailee Jani, Hyekyoung Sung, Gary Sweeney, Rolando B. Ceddia
Abstract
and p38 mitogen-activated protein kinase (MAPK) phosphorylations in either Epid or Sc Ing adipocytes. ALY688 did not alter basal lipolysis in Epid and Sc Ing adipocytes, but it enhanced isoproterenol-induced lipolysis in Epid adipocytes. Adiponectin receptor 2 (AdipoR2) mRNA was the prevalent isoform expressed in all adipocytes, and Epid adipocytes displayed significantly higher AdipoR2 mRNA expression than Sc Ing adipocytes. In conclusion, ALY688 can regulate adiposity and affect glycaemic control by altering substrate portioning in the WAT in a fat depot-specific manner.
Topics & Concepts
Internal medicineLipolysisEndocrinologyAdiponectinAdipose tissueAMPKGlucose uptakeCarbohydrate metabolismProtein kinase AAdipogenesisChemistryWhite adipose tissueAdipocyteLipid metabolismAdiponectin receptor 1InsulinBiologyKinaseInsulin resistanceBiochemistryMedicineAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismExercise and Physiological Responses