I<sub>2</sub>-mediated coupling of quinazolinone enamines with 2-aminopyridines: a new strategy to access spiroquinazolinones
Jingxi Fang, Zhentao Pan, Tong Liu, Yingbo Rao, Huajiang Jiang, Yongmin Ma
Abstract
an umpolung strategy mediated by molecular iodine. A library of functionalized spiroquinazolinone iodide salts was synthesized in moderate to good yields under ambient, metal-free and mild conditions. The current methodology opens up a new efficient and concise strategy for the construction of spiroquinazolinones.
Topics & Concepts
AminopyridinesChemistryQuinazolinoneCoupling (piping)Combinatorial chemistryBusinessMedicinal chemistryMetallurgyMaterials scienceQuinazolinone synthesis and applicationsN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic C–H Functionalization Methods