Visible-Light-Induced Decarboxylative Aminosulfonylation of (Hetero)aryl Carboxylic Oxime Esters
Zhen Zhuang, Yuting Sun, Yuanchen Zhong, Qian He, Xiaofei Zhang, Chunhao Yang
Abstract
Sulfonamides are important structures in pharmaceuticals, agrochemicals, and organocatalysts, yet the rapid and benign synthesis of these compounds is still a great challenge. Herein we report a photoinduced method for synthesizing sulfonamides from (hetero)aryl carboxylic acid oxime esters. This reaction proceeds via one-pot cascade radical–radical cross-coupling by energy-transfer-mediated photocatalysis. A wide substrate scope including (hetero)aryl substrates and late-stage modification of pharmaceutical molecular entities reveal its generality.
Topics & Concepts
ChemistryArylOximeSubstrate (aquarium)Aryl radicalCombinatorial chemistryPhotocatalysisDecarboxylationOrganic chemistryCarboxylic acidPhotochemistryCatalysisAlkylGeologyOceanographySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods