Exposome-wide association study of environmental chemical exposures and epigenetic aging in the national health and nutrition examination survey
Dennis Khodasevich, Nicole Gladish, Saher Daredia, Anne K. Bozack, Hanyang Shen, Jamaji C. Nwanaji‐Enwerem, Belinda L. Needham, David H. Rehkopf, Andrés Cárdenas
Abstract
serum cotinine levels was associated with higher GrimAge2 acceleration (beta = 1.40 years, p = 6.53e-04) and higher DunedinPoAm (beta = 0.03, p = 6.31e-04). Associations between cadmium and EAA across several clocks persisted in sensitivity models adjusted for serum cotinine levels, and other associations involving lead, dioxins, and PCBs were identified. Several environmental exposures are associated with epigenetic aging in a nationally representative US adult population, with particularly strong associations related to cadmium and cotinine across several epigenetic clocks.
Topics & Concepts
National Health and Nutrition Examination SurveyExposomeCotinineEpigeneticsEpigenomeMedicineCADMIUM EXPOSUREEnvironmental healthPhysiologyBiologyInternal medicineGeneticsPopulationDNA methylationGene expressionGeneNicotineToxicityEpigenetics and DNA MethylationHealth, Environment, Cognitive AgingBirth, Development, and Health