Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage
Zilan Song, Bo Liu, Xia Peng, Wangting Gu, Yiming Sun, Xing Li, Yi Xu, Meiyu Geng, Jing Ai, Ao Zhang
Abstract
is a promising candidate worthy of further investigation.
Topics & Concepts
ChemistrySmall moleculeLinkage (software)StereochemistryCD8PharmacologyBlockadePotencyStructure–activity relationshipLead compoundIC50Combinatorial chemistryImmune systemBiochemistryIn vitroReceptorImmunologyGeneMedicineBiologyCancer Immunotherapy and BiomarkersCAR-T cell therapy researchPeptidase Inhibition and Analysis