Accelerated Progression of Disseminated Coccidioidomycosis Following SARS-CoV-2 Infection: A Case Report
Daniel S. Krauth, Christina Jamros, Shayna C Rivard, Niels Olson, Ryan C. Maves
Abstract
We describe a patient with subclinical coccidioidomycosis who experienced rapid disease dissemination shortly after SARS-CoV-2 infection, suggesting host immune response dysregulation to coccidioidomycosis by SARS-CoV-2. We hypothesize that disrupted cell-mediated signaling may result after SARS-CoV-2 infection leading to functional exhaustion and CD8+ T-cell senescence with impairment in host cellular response to Coccidioides infection.
Topics & Concepts
MedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Virology2019-20 coronavirus outbreakPandemicBetacoronavirusOutbreakPathologyDiseaseInfectious disease (medical specialty)Fungal Infections and StudiesAntifungal resistance and susceptibilityNeutropenia and Cancer Infections