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Perfluorooctanoic acid promotes pancreatic β cell dysfunction and apoptosis through ER stress and the ATF4/CHOP/TRIB3 pathway

Xiaowei He, Dan Wu, Yanan Xu, Yaqin Zhang, Yue Sun, Xiaoai Chang, Yunxia Zhu, Wei Tang

2022Environmental Science and Pollution Research19 citationsDOI

Topics & Concepts

Unfolded protein responsePerfluorooctanoic acidApoptosisCHOPViability assayATF4EndocrinologyInternal medicineOxidative stressProgrammed cell deathEndoplasmic reticulumBiologyChemistryCell biologyCancer researchBiochemistryMedicinePer- and polyfluoroalkyl substances researchPancreatic function and diabetesBirth, Development, and Health
Perfluorooctanoic acid promotes pancreatic β cell dysfunction and apoptosis through ER stress and the ATF4/CHOP/TRIB3 pathway | Litcius