Screening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine
Thaila Fernanda dos Reis, Maria Augusta Crivelente Horta, Ana Cristina Colabardini, Caroline Mota Fernandes, Lilian Pereira Silva, Rafael Wesley Bastos, Maria Vitória de Lazari Fonseca, Fang Wang, Celso Martins, Márcio L. Rodrigues, Cristina Silva Pereira, Maurizio Del Poeta, Koon Ho Wong, Gustavo H. Goldman
Abstract
The filamentous fungus Aspergillus fumigatus causes a group of diseases named aspergillosis, and their development occurs after the inhalation of conidia dispersed in the environment. Very few classes of antifungal drugs are available for aspergillosis treatment, e.g., azoles, but the emergence of global resistance to azoles in A. fumigatus clinical isolates has increased over recent decades.
Topics & Concepts
Aspergillus fumigatusAspergillosisVoriconazoleAntifungalMiltefosineAntifungal drugDrugAzoleMedicineBiologyMicrobiologyImmunologyPharmacologyVisceral leishmaniasisLeishmaniasisAntifungal resistance and susceptibilityFungal Infections and StudiesInfectious Diseases and Mycology