Reaction of 3-Amino-5H- and 3-Amino-5-sulfanyl-1,2,4-triazoles with 1,2,4-Triazine-5-carbonitriles
Alexey P. Krinochkin, M. R. Guda, Dmitry S. Kopchuk, Ya. K. Shtaitz, Константин В. Саватеев, E. N. Ulomsky, Grigory V. Zyryanov, В. Л. Русинов, Олег Н. Чупахин
Abstract
Abstract 1,2,4-Triazines with an unsubstituted (1,2,4-triazol-3-yl)amine residue in the C5 position were synthesized by the solvent-free ipso-amination reaction between 1,2,4-triazine-5-carbonitriles and 3-amino-5H- or 3-amino-5-sulfanyl-1,2,4-triazoles. In the latter case, the reaction is accompanied by desulfurization of the 1,2,4-triazole fragment.
Topics & Concepts
ChemistrySulfanylTriazineAminationAmine gas treatingResidue (chemistry)1,2,4-TriazoleSolventCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryCatalysisSynthesis and Characterization of Heterocyclic CompoundsSynthesis of heterocyclic compoundsSynthesis and Biological Evaluation