Litcius/Paper detail

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

Shogo Kumagai, Yosuke Togashi, Takahiro Kamada, Eri Sugiyama, Hitomi Nishinakamura, Yoshiko Takeuchi, Vitaly Kochin, Kota Itahashi, Yuka Maeda, Shigeyuki Matsui, Takuma Shibahara, Yasuho Yamashita, Takuma Irie, Ayaka Tsuge, Shota Fukuoka, Akihito Kawazoe, Hibiki Udagawa, Keisuke Kirita, Keiju Aokage, Genichiro Ishii, Takeshi Kuwata, Kenta Nakama, Masahito Kawazu, Toshihide Ueno, Naoya Yamazaki, Kōichi Goto, Masahiro Tsuboi, Hiroyuki Mano, Toshihiko Doi, Kohei Shitara, Hiroyoshi Nishikawa

2020Nature Immunology813 citationsDOI

Topics & Concepts

BlockadeEffectorImmune checkpointPD-L1CD8Tumor microenvironmentCancer researchT cellMedicineBiomarkerImmune systemImmunotherapyImmunologyCytotoxic T cellBiologyInternal medicineReceptorBiochemistryIn vitroCancer Immunotherapy and BiomarkersCAR-T cell therapy researchImmune Cell Function and Interaction