PI3K/AKT activation attenuates acute kidney injury following liver transplantation by inducing FoxO3a nuclear export and deacetylation
Fanbing Meng, Zheng Zhang, Chaojin Chen, Yue Liu, Dongdong Yuan, Ziqing Hei, Gangjian Luo
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BApoptosisCancer researchLY294002Downregulation and upregulationFas ligandTransplantationAcute kidney injuryMedicineProgrammed cell deathCell biologySignal transductionChemistryBiologyInternal medicineBiochemistryGeneFOXO transcription factor regulationOrgan Transplantation Techniques and OutcomesLiver physiology and pathology