Chemical Exchanges between Multilateral Symbionts
Munhyung Bae, Emily Mevers, Gleb Pishchany, Sarah Whaley, Charles O. Rock, David R. Andes, Cameron R. Currie, Mônica Tallarico Pupo, Jon Clardy
Abstract
Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis.
Topics & Concepts
ChemistryFungusAntimicrobialBiosynthesisBacteriaPathogenic bacteriaStereochemistryMass spectrometryBiochemistryGeneOrganic chemistryBotanyGeneticsBiologyChromatographyMicrobial Natural Products and BiosynthesisEntomopathogenic Microorganisms in Pest ControlInsect symbiosis and bacterial influences