Recent advances in catalytic enantioselective construction of monofluoromethyl-substituted stereocenters
Bojie Li, Yu-Long Ruan, Lei Zhu, Jian Zhou, Jin‐Sheng Yu
Abstract
F-containing substrates. This feature article aims to summarize these recent advances and discusses the possible reaction mechanisms, advantages and limitations of each protocol and their applications. Synthetic opportunities still open for further development are illustrated as well. This review article will be an inspiration for researchers engaged in asymmetric catalysis, organofluorine chemistry, and medicinal chemistry.
Topics & Concepts
StereocenterEnantioselective synthesisCatalysisChemistryStereochemistryCombinatorial chemistryOrganic chemistryFluorine in Organic ChemistryCarbohydrate Chemistry and SynthesisSynthesis and Reactions of Organic Compounds