Quantifying the inflammatory secretome of human intermuscular adipose tissue
Darcy Kahn, Emily Macias, Simona Zarini, Amanda Garfield, Karin Zemski Berry, Robert E. Gerszten, Jonathan A. Schoen, Melanie Cree‐Green, Bryan C. Bergman
Abstract
, 5-HETE, and 12-HETE) compared to SAT and/or VAT. In the context of obesity, IMAT is a distinct adipose tissue with a highly immunogenic and inflammatory secretome, and given its proximity to skeletal muscle, may be critical to glucose regulation and insulin resistance.
Topics & Concepts
Adipose tissueMedicineInflammationPathologyBioinformaticsComputational biologyBiologyImmunologyInternal medicineAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism