Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput
Patrick H. Kennedy, Amin Alborzian Deh Sheikh, Matthew Balakar, Alexander C. Jones, Meagan E. Olive, Mudra Hegde, Maria I. Matias, Natan Pirete, Rajan A. Burt, Jonathan M. Levy, Tamia Little, Patrick G. Hogan, David R. Liu, John G. Doench, Alexandra C. Newton, Rachel A. Gottschalk, Carl G. de Boer, Suzie Alarcón, Gregory A. Newby, Samuel A. Myers
Topics & Concepts
PhosphoproteomicsPhosphorylationNFATBiologyComputational biologyFunction (biology)PhenotypeRegulation of gene expressionSignal transductionCell biologyProtein phosphorylationGeneTranscription factorGeneticsProtein kinase ACRISPR and Genetic EngineeringViral Infectious Diseases and Gene Expression in InsectsSignaling Pathways in Disease