Lipid-induced DRAM recruits STOM to lysosomes and induces LMP to promote exosome release from hepatocytes in NAFLD
Jie Zhang, Jie Tan, Mengke Wang, Yifen Wang, Mengzhen Dong, Xuefeng Ma, Baokai Sun, Shousheng Liu, Zhenzhen Zhao, Lizhen Chen, Kai Liu, Yongning Xin, Likun Zhuang
Abstract
knockout mice. Last, FA-induced DRAM interacted with stomatin and promoted its lysosomal localization to enhance exosome secretion from hepatic cells. We revealed a DRAM-mediated mechanism for exosome secretion and provided the foundation for plasma exosomes as a potential biomarker for NAFLD.
Topics & Concepts
ExosomeGene knockdownMicrovesiclesLysosomeSecretionAutophagyKnockout mouseCell biologyChemistryBiologyCancer researchEndocrinologyBiochemistryApoptosismicroRNAGeneEnzymeExtracellular vesicles in diseaseLiver Disease Diagnosis and TreatmentMicroRNA in disease regulation