Palladium-Catalyzed Carbonylative Sonogashira Coupling of Aryl Thianthrenium Salts with Arylalkynes
Yanhua Zhao, Xing‐Wei Gu, Xiao‐Feng Wu
Abstract
Alkynones are valuable compounds with applications in various areas. In this work, we developed an efficient carbonylation procedure for the carbonylative cross-coupling of aryl thianthrenium salts with aromatic alkynes. Various useful alkynones were produced in moderate to excellent yields under mild conditions. Notably, among the various tolerated functional groups, the bromide group can be maintained, which is ready for further coupling reactions.
Topics & Concepts
Sonogashira couplingChemistryArylCarbonylationPalladiumCatalysisBromideCombinatorial chemistryOrganic chemistryCarbon monoxideAlkylCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques