The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini
Ajitesh Lunge, Radhika Gupta, Eira Choudhary, Nisheeth Agarwal
Abstract
transcripts. In summary, the cellular levels of oligomeric proteins such as Hsp20 are maintained post-translationally through their recognition, disassembly, and degradation by ClpC1, which requires disordered ends in its protein substrates.
Topics & Concepts
BiologyMycobacterium tuberculosisProteaseHeat shock proteinGene knockdownCell biologyGene silencingProtein subunitProteasesGeneBiochemistryTuberculosisEnzymeMedicinePathologyHeat shock proteins researchProtein Structure and DynamicsEnzyme Structure and Function