Cellular Protein HuR Regulates the Switching of Genomic RNA Templates for Differential Functions during the Coxsackievirus B3 Life Cycle
Biju George, Pratik Dave, Priya Rani, P. Behera, Saumitra Das
Abstract
A positive-strand RNA virus must balance the availability of its genomic template for different viral processes at different stages of its life cycle. A few host proteins are shown to be important to help the virus in switching the usage of a template between these processes. These proteins inhibit translation either by displacing a stimulator of translation or by binding to an alternative site. Both mechanisms lead to ribosome clearance and availability of the genomic strand for replication. We have shown that HuR also helps in maintaining this balance by inhibiting replication and subsequently promoting translation and packaging.
Topics & Concepts
Internal ribosome entry siteBiologyRNAViral replicationRNA silencingTranslation (biology)Untranslated regionNon-coding RNAVirologyCell biologyGeneticsRibosomeMessenger RNAVirusRNA interferenceGeneViral Infections and Immunology ResearchRNA and protein synthesis mechanismsRNA Research and Splicing