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Discovery of pomalidomide-based PROTACs for selective degradation of histone deacetylase 8

Zhiqiang Sun, Bulian Deng, Zichao Yang, Ruiyao Mai, Junli Huang, Zeli Ma, Ting Chen, Jianjun Chen

2022European Journal of Medicinal Chemistry40 citationsDOI

Topics & Concepts

HDAC8ChemistryHistone deacetylaseAcetylationUbiquitinHDAC6HDAC1BiochemistryProteolysisPomalidomideHistoneEnzymeBiologyBortezomibGeneMultiple myelomaImmunologyHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsPeptidase Inhibition and Analysis
Discovery of pomalidomide-based PROTACs for selective degradation of histone deacetylase 8 | Litcius