Lactate drives the ESM1–SCD1 axis to inhibit the antitumor CD8+ T-cell response by activating the Wnt/β-catenin pathway in ovarian cancer cells and inducing cisplatin resistance
Zhiwen Fan, Mingzhu Ye, Dan Liu, Wenchao Zhou, Tian Zeng, Sili He, Yukun Li
Topics & Concepts
Wnt signaling pathwayCisplatinOvarian cancerCD8CateninCancer researchPharmacologyChemistryBiologyMedicineCancerCell biologyInternal medicineImmunologyImmune systemSignal transductionChemotherapyApelin-related biomedical researchGalectins and Cancer BiologyCircular RNAs in diseases