Palladium-Catalyzed Asymmetric Desymmetrization for the Simultaneous Construction of Chiral Phosphorus and Quaternary Carbon Stereocenters
Hengrui Zhou, Yiji Xue, Xiang Zhou, Hequan Yao, Aijun Lin
Abstract
A palladium-catalyzed asymmetric tandem Heck and carbonylation of bisallyl-phosphine oxides has been developed. This desymmetrization process provided an efficient route to the simultaneous synthesis of a chiral P-stereogenic center and a chiral quaternary carbon stereocenter in good yields with good diastereo- and enantioselectivities.
Topics & Concepts
DesymmetrizationStereocenterChemistryPalladiumCatalysisPhosphorusCarbon fibersOrganic chemistryEnantioselective synthesisQuaternary carbonQuaternaryCombinatorial chemistryMaterials scienceBiologyComposite numberComposite materialPaleontologyAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisChemical Synthesis and Analysis