Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications
Tan Liu, Xiaojie Ma, Jiahui Yu, Wensheng Yang, Guiyang Wang, Zhengdong Wang, Yuanjie Ge, Juan Song, Hua Han, Wen Zhang, Donghui Yang, Xuehui Liu, Ming Ma
Abstract
possess antagonistic activities against the binding of lipopolysaccharides to toll-like receptor 4 (TLR4). These results demonstrate proof-of-concept for the combined mutational/chemical generation of lasso peptide libraries to support drug lead development.
Topics & Concepts
GeneComputational biologyPeptideLasso (programming language)Rational designGeneticsBiologyChemistryBiochemistryComputer scienceWorld Wide WebMicrobial Natural Products and BiosynthesisChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies Research