Iridium‐Catalyzed Asymmetric Allylic Benzylation with Photogenerated Hydroxy‐<i>o</i>‐Quinodimethanes
Pusu Yang, Ruixiang Wang, Yuan‐Zheng Cheng, Chao Zheng, Shu‐Li You
Abstract
An iridium-catalyzed asymmetric allylic benzylation of aryl vinyl carbinols under light irradiation is described. 2-Methylbenzophenone derivatives are employed and activated to hydroxy-o-quinodimethanes by an ultraviolet (UV) light. This approach enables asymmetric allylic benzylation with high enantioselectivity (up to 99 % ee) from readily available 2-methylbenzophenones without the utilization of strong bases, and pre-activation or pre-functionalization of the substrates. Moreover, deuterium experiments reveal the generation of nucleophilic benzyl species from 2-methylbenzophenone under UV irradiation.
Topics & Concepts
IridiumAllylic rearrangementCatalysisChemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisRadical Photochemical Reactions