Tumor Targeting of <sup>211</sup>At-Labeled Antibody under Sodium Ascorbate Protection against Radiolysis
Hiroki Takashima, Kazunobu Ohnuki, Shino Manabe, Yoshikatsu Koga, Ryo Tsumura, Takahiro Anzai, Yang Wang, Xiaojie Yin, Nozomi Sato, Yudai Shigekawa, Akihiro Nambu, Sachiko Usuda, Hiromitsu Haba, Hirofumi Fujii, Masahiro Yasunaga
Abstract
At, active targeting contributes to efficient tumor accumulation of radioactivity, resulting in a potent antitumor effect. SA-dependent protection that successfully maintains tumor targeting will facilitate the clinical application of alpha-RIT.
Topics & Concepts
ChemistryRadioimmunotherapyMonoclonal antibodyAntibodyImmunoconjugateRadiolysisDenaturation (fissile materials)Sodium ascorbateIn vivoBiodistributionBiophysicsBiochemistryIn vitroRadicalAscorbic acidImmunologyBiologyBiotechnologyFood scienceNuclear chemistryRadiopharmaceutical Chemistry and ApplicationsMonoclonal and Polyclonal Antibodies ResearchHER2/EGFR in Cancer Research