Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells
Evert Njomen, Rachel E. Hayward, Kristen E. DeMeester, Daisuke Ogasawara, Melissa M. Dix, Tracey Nguyen, Paige Ashby, Gabriel M. Simon, Stuart L. Schreiber, Bruno Melillo, Benjamin F. Cravatt
Topics & Concepts
ChemistryProteomeCysteineChemical biologyElectrophileProtein–protein interactionHuman proteome projectBiochemistryCovalent bondComputational biologyProteomicsCancer cellCombinatorial chemistryGeneEnzymeCancerBiologyGeneticsOrganic chemistryCatalysisClick Chemistry and ApplicationsUbiquitin and proteasome pathwaysProtein Degradation and Inhibitors