A short isoform of STIM1 confers frequency-dependent synaptic enhancement
Girish Ramesh, Lukas Jarzembowski, Yvonne Schwarz, Vanessa Poth, Maik Konrad, Mona L. Knapp, Gertrud Schwär, Anna Andrea Lauer, Marcus O.W. Grimm, Dalia Alansary, Dieter Bruns, Barbara A. Niemeyer
Abstract
- and Orai-dependent short-term synaptic enhancement (STE) at high-frequency stimulation (HFS). In conjunction with altered STIM1 splicing in human Alzheimer disease, our findings highlight STIM1 splicing as an important regulator of neuronal calcium homeostasis and of synaptic plasticity.
Topics & Concepts
STIM1Cell biologyEndoplasmic reticulumAlternative splicingGatingSynaptic plasticityBiologyRNA splicingGene isoformCalcium signalingHomeostasisChemistryNeuroscienceReceptorSignal transductionBiochemistryRNAGeneIon Channels and ReceptorsBiochemical Analysis and Sensing TechniquesPhytochemicals and Antioxidant Activities