Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade
Daniel Ajona, Sergio Ortiz‐Espinosa, Teresa Lozano, Francisco Expósito, Alfonso Calvo, Karmele Valencia, Miriam Redrado, Ana Remírez, Fernando Lecanda, Diego Alignani, Juan José Lasarte, Irati Macaya, Yaiza Senent, Cristina Bértolo, Cristina Sainz, Ignacio Gil‐Bazo, Iñaki Eguren‐Santamaría, José M. López-Picazo, Álvaro González, José Luis Perez‐Gracia, Carlos E. de Andrea, Silvestre Vicent, Miguel F. Sanmamed, Luis M. Montuenga, Rubén Pı́o
Topics & Concepts
BlockadePD-L1CD8Cancer researchImmunotherapyDownregulation and upregulationImmune systemLung cancerImmune checkpointProgrammed cell deathMetastasisMedicineT cellGrowth factorReceptorCancerBiologyImmunologyInternal medicineApoptosisBiochemistryGeneCancer, Hypoxia, and MetabolismCancer Cells and MetastasisCytokine Signaling Pathways and Interactions