ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway
Peng Zeng, Jie Yang, Lipei Liu, Xiaoxiao Yang, Zhi Yao, Chuanrui Ma, Haibo Zhu, Jiamin Su, Qian Zhao, Ke Feng, Shu Yang, Yan Zhu, Xiaoju Li, Wenguang Wang, Yajun Duan, Jihong Han, Yuanli Chen
Abstract
: Our study demonstrates that activation of miR-126-3p production in ECs/SMCs and interactions between ECs and SMCs play an important role in reduction of vascular calcification by ERK1/2 inhibition.
Topics & Concepts
DKK1LRP6CalcificationChemistryWnt signaling pathwayVascular smooth muscleCell biologySignal transductionCancer researchBiologyInternal medicineMedicineBiochemistrySmooth muscleProtein Tyrosine PhosphatasesDermatological and Skeletal DisordersParathyroid Disorders and Treatments